Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species

Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species

Background/Aims: Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) is promising for the treatment of inflammatory disorders, however, the efficacy of p38 MAPK inhibitors in clinical trials is limited so far. Since functional sensitivity of p38 MAPK is commonly predicted by preclinical sp...

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Bibliographic Details
Main Authors: Sarah Fehr, Anke Unger, Elke Schaeffeler, Sonja Herrmann, Stefan Laufer, Matthias Schwab, Wofgang Albrecht
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
p38 MAP
Kinase TNF-α
Species Differences
Whole Blood
Online Access:http://www.karger.com/Article/FullText/430188

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