Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.

Bibliographic Details
Main Authors:	Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu, Zhiwei Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05746-9

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spelling	doaj-ed18969fb27e4c749a94ac8b64c9a7f72021-05-11T10:18:57ZengNature Publishing GroupNature Communications2041-17232018-08-019111510.1038/s41467-018-05746-9Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infectionPeixin Song0Nan Zheng1Yong Liu2Chen Tian3Xilin Wu4Xiaohua Ma5Deyan Chen6Xue Zou7Guiyang Wang8Huanru Wang9Yongyang Zhang10Sufang Lu11Chao Wu12Zhiwei Wu13Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolCenter for Public Health Research, Nanjing University Medical SchoolDepartment of Experimental Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolCenter for Public Health Research, Nanjing University Medical SchoolY-Clone BioMedical, Ltd., Suzhou Hi-Tech Innovation ParkCenter for Public Health Research, Nanjing University Medical SchoolCenter for Public Health Research, Nanjing University Medical SchoolDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolCenter for Public Health Research, Nanjing University Medical SchoolDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolCenter for Public Health Research, Nanjing University Medical SchoolSFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.https://doi.org/10.1038/s41467-018-05746-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peixin Song Nan Zheng Yong Liu Chen Tian Xilin Wu Xiaohua Ma Deyan Chen Xue Zou Guiyang Wang Huanru Wang Yongyang Zhang Sufang Lu Chao Wu Zhiwei Wu
spellingShingle	Peixin Song Nan Zheng Yong Liu Chen Tian Xilin Wu Xiaohua Ma Deyan Chen Xue Zou Guiyang Wang Huanru Wang Yongyang Zhang Sufang Lu Chao Wu Zhiwei Wu Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection Nature Communications
author_facet	Peixin Song Nan Zheng Yong Liu Chen Tian Xilin Wu Xiaohua Ma Deyan Chen Xue Zou Guiyang Wang Huanru Wang Yongyang Zhang Sufang Lu Chao Wu Zhiwei Wu
author_sort	Peixin Song
title	Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_short	Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_full	Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_fullStr	Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_full_unstemmed	Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
title_sort	deficient humoral responses and disrupted b-cell immunity are associated with fatal sftsv infection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.
url	https://doi.org/10.1038/s41467-018-05746-9
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Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

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