Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor, GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the intervening time, a deeper understanding of the role of the autotaxin−lysophosphatidate (LPA)−li...

Full description

Bibliographic Details
Main Authors:	Matthew G. K. Benesch, Xiaoyun Tang, David N. Brindley
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Cancers
Subjects:	lysophosphatidic acid lipid phosphate phosphatases glpg1690 chemoresistance radiotherapy metastasis tumor microenvironment
Online Access:	https://www.mdpi.com/2072-6694/12/2/374

Similar Items

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation
by: Matthew G.K. Benesch, et al.
Published: (2018-03-01)

Autotaxin, lysophosphatidate and taxol resistance
by: Samadi, Nasser
Published: (2009)

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling
by: Zelei Yang, et al.
Published: (2021-09-01)

Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease
by: Anu Jose, et al.
Published: (2021-09-01)

LPA receptor 4 deficiency attenuates experimental atherosclerosis
by: Liping Yang, et al.
Published: (2019-05-01)

Autotaxin promotes cancer cell invasion via the lysophosphatidic acid receptor 4
by: Harper, Kelly
Published: (2010)

Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell Surface
by: Olivier Peyruchaud, et al.
Published: (2019-12-01)

Autotaxin in Pathophysiology and Pulmonary Fibrosis
by: Ioanna Ninou, et al.
Published: (2018-06-01)

Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
by: Eunah Shin, et al.
Published: (2019-08-01)

Expression of Autotaxin–Lysophosphatidate Signaling-Related Proteins in Breast Cancer with Adipose Stroma
by: Yoon Jin Cha, et al.
Published: (2019-04-01)

Autotaxin–Lysophosphatidic Acid Signaling in Alzheimer’s Disease
by: Sindhu Ramesh, et al.
Published: (2018-06-01)

Persuasion and conviction in the language of thought and action 1690-1710
by: Hardy, George Brett
Published: (1987)

The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions
by: Fernando Salgado-Polo, et al.
Published: (2019-10-01)

Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
by: C. Chris Yun
Published: (2019-07-01)

The Expression Regulation and Biological Function of Autotaxin
by: Xiaotian Zhang, et al.
Published: (2021-04-01)

Lipid phosphate phosphatases and signaling
by: David N. Brindley, et al.
Published: (2009-01-01)

ADSCs and adipocytes are the main producers in the autotaxin–lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro
by: Rafael Schmid, et al.
Published: (2018-12-01)

Autotaxin: structure-function and signaling
by: Anastassis Perrakis, et al.
Published: (2014-06-01)

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
by: Youngjin Han, et al.
Published: (2019-02-01)

Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment
by: Yan Xu
Published: (2018-07-01)

Increased β‐endorphin and autotaxin in patients with prurigo
by: Takahiro Ishikawa, et al.
Published: (2019-08-01)

Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling
by: Kuan-Hung Lin, et al.
Published: (2020-03-01)

Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target
by: Konstantinos Ntatsoulis, et al.
Published: (2021-10-01)

Convergence of vitamin D and lysophosphatidic acid signalling in stimulating human osteoblast maturation.
by: Jason Peter Mansell
Published: (2014-07-01)

Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality
by: Shuang Wang, et al.
Published: (2021-08-01)

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease
by: María Flores-López, et al.
Published: (2021-09-01)

Residue-by-residue analysis of cotranslational membrane protein integration in vivo
by: Felix Nicolaus, et al.
Published: (2021-02-01)

Actividad teatral en Cádiz a finales del siglo xvii (1690-1700)
by: José María Lázaro Bruña
Published: (2020-03-01)

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier
by: Martina Da Ros, et al.
Published: (2018-09-01)

Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions
by: Xin Zhang, et al.
Published: (2019-01-01)

Lipid Phosphate Phosphatases and Cancer
by: Xiaoyun Tang, et al.
Published: (2020-09-01)

Caractérisation in vivo du rôle de phosphatases de la famille PS2;1 à 3, marqueurs précoces de la carence en phosphate chez Arabidopsis thaliana
by: Hanchi, Mohamed
Published: (2017)

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
by: Francesca Megiorni, et al.
Published: (2017-10-01)

Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
by: Sistiana Aiello, et al.
Published: (2021-06-01)

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer
by: Li, X., et al.
Published: (2022)

Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death
by: Jean-Pierre Delord, et al.
Published: (2012-07-01)

Daseinsvorsorge aus Bürgersicht - Bewertung der Lebensverhältnisse und Daseinsvorsorge vor dem Hintergrund der infrastrukturellen Ausstattung sächsischer Dörfer
by: Kunz, Angela, et al.
Published: (2009)

Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer
by: David N. Brindley, et al.
Published: (2020-08-01)

Divulging the Critical Role of HuR in Pancreatic Cancer as a Therapeutic Target and a Means to Overcome Chemoresistance
by: Dimitrios Goutas, et al.
Published: (2021-09-01)

Autoxidation as a cause of altered lipid distribution in extracts from human red cells
by: James T. Dodge, et al.
Published: (1966-05-01)