Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

Huntington's disease (HD) is caused by an expansion of glutamine repeats in the huntingtin protein (mHtt) that invokes early and prominent damage of the striatum, a region that controls motor behaviors. Despite its ubiquitous expression, why certain brain regions, such as the cerebellum, are re...

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Bibliographic Details
Main Authors: Supriya Swarnkar, Youjun Chen, William M. Pryor, Neelam Shahani, Damon T. Page, Srinivasa Subramaniam
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Cerebellar pathology
Ectopic expression
Soluble Huntingtin
Neuronal death
Stereotaxy
Knock-in HD mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001850

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http://www.sciencedirect.com/science/article/pii/S0969996115001850

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