Circulating biomarkers for early detection of hepatocellular carcinoma

Circulating biomarkers for early detection of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allows for curative surgical treatment and therefore s...

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Main Authors: Boris J. B. Beudeker, Andre Boonstra
Format: Article
Language:English
Published: SAGE Publishing 2020-06-01
Series:Therapeutic Advances in Gastroenterology
Online Access:https://doi.org/10.1177/1756284820931734
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spelling doaj-ed0d85501a764cc0a702b73eb6b3c2f02020-11-25T03:54:56ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482020-06-011310.1177/1756284820931734Circulating biomarkers for early detection of hepatocellular carcinomaBoris J. B. BeudekerAndre BoonstraHepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allows for curative surgical treatment and therefore saves lives. Specific non-invasive or diagnostic markers for HCC may represent a valuable tool for detecting these tumors at an early stage. The clinically most established serological biomarker alpha-fetoprotein shows only limited diagnostic performance, however novel candidate biomarkers and biomarker panels for detecting HCC at early stages of development are being studied. In this review we will discuss the findings of these studies.https://doi.org/10.1177/1756284820931734
collection DOAJ
language English
format Article
sources DOAJ
author Boris J. B. Beudeker
Andre Boonstra
spellingShingle Boris J. B. Beudeker
Andre Boonstra
Circulating biomarkers for early detection of hepatocellular carcinoma
Therapeutic Advances in Gastroenterology
author_facet Boris J. B. Beudeker
Andre Boonstra
author_sort Boris J. B. Beudeker
title Circulating biomarkers for early detection of hepatocellular carcinoma
title_short Circulating biomarkers for early detection of hepatocellular carcinoma
title_full Circulating biomarkers for early detection of hepatocellular carcinoma
title_fullStr Circulating biomarkers for early detection of hepatocellular carcinoma
title_full_unstemmed Circulating biomarkers for early detection of hepatocellular carcinoma
title_sort circulating biomarkers for early detection of hepatocellular carcinoma
publisher SAGE Publishing
series Therapeutic Advances in Gastroenterology
issn 1756-2848
publishDate 2020-06-01
description Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allows for curative surgical treatment and therefore saves lives. Specific non-invasive or diagnostic markers for HCC may represent a valuable tool for detecting these tumors at an early stage. The clinically most established serological biomarker alpha-fetoprotein shows only limited diagnostic performance, however novel candidate biomarkers and biomarker panels for detecting HCC at early stages of development are being studied. In this review we will discuss the findings of these studies.
url https://doi.org/10.1177/1756284820931734
work_keys_str_mv AT borisjbbeudeker circulatingbiomarkersforearlydetectionofhepatocellularcarcinoma
AT andreboonstra circulatingbiomarkersforearlydetectionofhepatocellularcarcinoma
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