Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer

Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer

Background: Serine Threonine Kinase 11 (STK11), also known as LKB1, is a tumor suppressor gene that regulates several biological processes such as apoptosis, energetic metabolism, proliferation, invasion, and migration. During malignant progression, different types of cancer inhibit STK11 function b...

Full description

Bibliographic Details
Main Authors:	Gabriela Figueroa-González, José F. Carrillo-Hernández, Itzel Perez-Rodriguez, David Cantú de León, Alma D. Campos-Parra, Antonio D. Martínez-Gutiérrez, Jossimar Coronel-Hernández, Verónica García-Castillo, César López-Camarillo, Oscar Peralta-Zaragoza, Nadia J. Jacobo-Herrera, Mariano Guardado-Estrada, Carlos Pérez-Plasencia
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Genes
Subjects:	microRNA mir-100 <i>STK11</i> promoter methylation head and neck cancer
Online Access:	https://www.mdpi.com/2073-4425/11/9/1058

Similar Items

Serine/Threonine Protein Kinase STK16
by: Junjun Wang, et al.
Published: (2019-04-01)

Molekulare und funktionelle Charakterisierung der Serin/Threonin-Proteinkinase Stk und -Proteinphosphatase Stp von \(Staphylococcus\) \(aureus\)
by: Jarick, Marcel
Published: (2020)

The Importance of <i>STK11</i>/<i>LKB1</i> Assessment in Non-Small Cell Lung Carcinomas
by: Baharia Mograbi, et al.
Published: (2021-01-01)

Somatic mutations of <it>STK11</it> gene in human papillomavirus positive and negative penile cancer
by: Annunziata Clorinda, et al.
Published: (2013-01-01)

Prevalence of the STK15 F31I polymorphism and its relationship with mammographic density
by: J. Giacomazzi, et al.
Published: (2011-04-01)

Prevalence of the STK15 F31I polymorphism and its relationship with mammographic density
by: J. Giacomazzi, et al.
Published: (2011-04-01)

STK11 gene mutations among patients with sporadic breast cancer
by: Antov Georgi, et al.
Published: (2017-01-01)

Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells
by: Zhong Wu, et al.
Published: (2018-01-01)

The pattern of STK11 gene mutation and its phenotypical manifestation in patient with hamartomas polyposis
by: M. R. Lozynska, et al.
Published: (2014-04-01)

Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory
by: David Levitan, et al.
Published: (2020-08-01)

Relationship between serine/threonine kinase 39 gene polymorphisms with some cardiac biomarkers in hypertensive patients
by: Fadhil Jawad Al-Tu’ma, et al.
Published: (2016-01-01)

Comparative Analysis of Stk11/Lkb1 Versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9
by: Martin F. Berthelsen, et al.
Published: (2021-02-01)

Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma
by: Zhenqing Li, et al.
Published: (2020-12-01)

miR-424 Promotes Bovine Adipogenesis Through an Unconventional Post-Transcriptional Regulation of STK11
by: Li Wang, et al.
Published: (2020-03-01)

Using High Resolution Melting method for detecting nucleotide polymorphisms of STK11 gene germline in patients with digestive system cancers
by: Seyed Jamal Hosseini, et al.
Published: (2017-11-01)

Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation
by: Wei Nie, et al.
Published: (2021-01-01)

Mutations in the serine/threonine protein kinase gene, STK11, in sporadic colorectal cancer
by: Engelbrecht, Sonja Teresa
Published: (2013)

Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species‐specific regulation of blood pressure
by: Carlo J. Mercado, et al.
Published: (2020-02-01)

Rôle des sérine/thréonine protéine-kinases dans la virulence de Staphylococcus aureus
by: Didier, Jean-Philippe
Published: (2009)

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer
by: Corrin A. Wohlhieter, et al.
Published: (2020-12-01)

STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors
by: Yohei Kojima, et al.
Published: (2020-10-01)

Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression
by: Kwack WG, et al.
Published: (2020-09-01)

Downregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation
by: Cheng‐Han Lin, et al.
Published: (2020-10-01)

Deleterious mis‐splicing of STK11 caused by a novel single‐nucleotide substitution in the 3′ polypyrimidine tract of intron five
by: Thorkild Terkelsen, et al.
Published: (2020-09-01)

Everolimus plus anastrozole for female adnexal tumor of probable Wolffian origin (FATWO) with STK11 mutation
by: Maria de Pilar Estevez-Diz, et al.
Published: (2021-08-01)

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome
by: Yu-Liang Jiang, et al.
Published: (2018-08-01)

Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene
by: Yu-Liang Jiang, et al.
Published: (2019-05-01)

STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma
by: Zhao Q, et al.
Published: (2018-03-01)

Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor
by: Calwing Liao, et al.
Published: (2020-07-01)

Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl
by: Zi-Ye Zhao, et al.
Published: (2018-04-01)

STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer
by: Haojun Yang, et al.
Published: (2020-10-01)

The Management of Peutz–Jeghers Syndrome: European Hereditary Tumour Group (EHTG) Guideline
by: Anja Wagner, et al.
Published: (2021-01-01)

Tyr198 is the Essential Autophosphorylation Site for STK16 Localization and Kinase Activity
by: Junjun Wang, et al.
Published: (2019-09-01)

Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Staphylococcus aureus
by: Weihao Zheng, et al.
Published: (2018-04-01)

Investigating the Roles of the Stk Locus in Development, Motility and Exopolysaccharide Production in Myxococcus Xanthus
by: Lauer, Pamela L. M.
Published: (2014)

Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38
by: Jian Chen, et al.
Published: (2021-01-01)

Étude structurale et fonctionnelle d’une sérine/thréonine kinase de staphylococcus aureus
by: Paracuellos torrecilla, Patricia
Published: (2009)

Identical Twins with a Mutation in the STK4 Gene Showing Clinical Manifestations of the Mutation at Different Ages: A Case Report
by: Farhad Abolnezhadian, et al.
Published: (2020-12-01)

Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient
by: Zi-Ye Zhao, et al.
Published: (2017-11-01)

A novel <it>de novo </it>mutation in the serine-threonine kinase <it>STK11 </it>gene in a Korean patient with Peutz-Jeghers syndrome
by: Ki Chang-Seok, et al.
Published: (2008-05-01)