Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication

Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication

<p>Abstract</p> <p>Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the vir...

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Bibliographic Details
Main Authors: Kesic Matthew J, Hernandez Michelle, Jaspers Ilona
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Respiratory Research
Subjects:
Asthma
Influenza A
Protease
Antiprotease
SLPI
TMPRSS2
Hemagglutinin
Susceptibility
Online Access:http://respiratory-research.com/content/13/1/82

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http://respiratory-research.com/content/13/1/82

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