Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents
Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases....
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2009-01-01
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Series: | International Journal of Rheumatology |
Online Access: | http://dx.doi.org/10.1155/2009/346136 |
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doaj-ecf04732dc794324b6900457cd1c22882020-11-24T23:52:11ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792009-01-01200910.1155/2009/346136346136Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic AgentsJoanna Rosalind Cunnington0Ramesh Jois1Ivan Zammit2David Scott3John Isaacs4Musculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UKMusculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UKMusculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UKMusculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UKMusculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UKWegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis who were treated with biologic agents. All three cases showed clinical response to treatment with biologic agents including rituximab and alemtuzumab and two cases demonstrated improvement in pituitary gland abnormalities by MRI. Clinicians should be aware that diabetes insipidus can present as a complication of Wegener's granulomatosis and that biologic therapies may be effective in refractory cases.http://dx.doi.org/10.1155/2009/346136 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Rosalind Cunnington Ramesh Jois Ivan Zammit David Scott John Isaacs |
spellingShingle |
Joanna Rosalind Cunnington Ramesh Jois Ivan Zammit David Scott John Isaacs Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents International Journal of Rheumatology |
author_facet |
Joanna Rosalind Cunnington Ramesh Jois Ivan Zammit David Scott John Isaacs |
author_sort |
Joanna Rosalind Cunnington |
title |
Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents |
title_short |
Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents |
title_full |
Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents |
title_fullStr |
Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents |
title_full_unstemmed |
Diabetes Insipidus as a Complication of Wegener's Granulomatosis and Its Treatment with Biologic Agents |
title_sort |
diabetes insipidus as a complication of wegener's granulomatosis and its treatment with biologic agents |
publisher |
Hindawi Limited |
series |
International Journal of Rheumatology |
issn |
1687-9260 1687-9279 |
publishDate |
2009-01-01 |
description |
Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis who were treated with biologic agents. All three cases showed clinical response to treatment with biologic agents including rituximab and alemtuzumab and two cases demonstrated improvement in pituitary gland abnormalities by MRI. Clinicians should be aware that diabetes insipidus can present as a complication of Wegener's granulomatosis and that biologic therapies may be effective in refractory cases. |
url |
http://dx.doi.org/10.1155/2009/346136 |
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