Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

Previous studies have reported higher biological activity of dehydrorosinamine derivatives. In order to further synthesize novel compounds with higher biological activity, a series of novel compounds containing benzo-azepine structures were synthesized from dehydroabietylamine in good yields in this...

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Main Authors:	Jincai Li, Chaoxiang Liu
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Series:	Heliyon
Subjects:	Natural product chemistry Organic chemistry Theoretical chemistry Dehydroabietylamine Antitumor DNA cleavage activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844020302358

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spelling	doaj-ece72ca55e93475a9856437f59ecaf012020-11-25T03:16:37ZengElsevierHeliyon2405-84402020-02-0162e03390Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivativesJincai Li0Chaoxiang Liu1Department of Pharmacy, Bozhou Vocational and Technical College, Bozhou 236800, PR ChinaDepartment of Pharmacy, Bozhou Vocational and Technical College, Bozhou 236800, PR China; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China; Corresponding author.Previous studies have reported higher biological activity of dehydrorosinamine derivatives. In order to further synthesize novel compounds with higher biological activity, a series of novel compounds containing benzo-azepine structures were synthesized from dehydroabietylamine in good yields in this study. The structures of synthesized compounds were identified by infra red (IR), 1H-NMR, 13C-NMR, and mass spectra (MS) analysis. The antitumor activities of the target compounds against L02 and HepG2 cells were studied. Furthermore, the dehydroabietylamine derivatives were studied on plasmid DNA cleavage activities. The results showed that the synthesized target compound exhibit antitumor and DNA cleavage activities against plasmid DNA (Escherichia coli). Our results further demonstrate the relationship between the chemical structure and biological function of the synthesized compounds.http://www.sciencedirect.com/science/article/pii/S2405844020302358Natural product chemistryOrganic chemistryTheoretical chemistryDehydroabietylamineAntitumorDNA cleavage activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jincai Li Chaoxiang Liu
spellingShingle	Jincai Li Chaoxiang Liu Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives Heliyon Natural product chemistry Organic chemistry Theoretical chemistry Dehydroabietylamine Antitumor DNA cleavage activity
author_facet	Jincai Li Chaoxiang Liu
author_sort	Jincai Li
title	Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives
title_short	Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives
title_full	Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives
title_fullStr	Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives
title_full_unstemmed	Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives
title_sort	synthesis, antitumor and dna cleavage activities of a novel class of dehydroabietylamine derivatives
publisher	Elsevier
series	Heliyon
issn	2405-8440
publishDate	2020-02-01
description	Previous studies have reported higher biological activity of dehydrorosinamine derivatives. In order to further synthesize novel compounds with higher biological activity, a series of novel compounds containing benzo-azepine structures were synthesized from dehydroabietylamine in good yields in this study. The structures of synthesized compounds were identified by infra red (IR), 1H-NMR, 13C-NMR, and mass spectra (MS) analysis. The antitumor activities of the target compounds against L02 and HepG2 cells were studied. Furthermore, the dehydroabietylamine derivatives were studied on plasmid DNA cleavage activities. The results showed that the synthesized target compound exhibit antitumor and DNA cleavage activities against plasmid DNA (Escherichia coli). Our results further demonstrate the relationship between the chemical structure and biological function of the synthesized compounds.
topic	Natural product chemistry Organic chemistry Theoretical chemistry Dehydroabietylamine Antitumor DNA cleavage activity
url	http://www.sciencedirect.com/science/article/pii/S2405844020302358
work_keys_str_mv	AT jincaili synthesisantitumoranddnacleavageactivitiesofanovelclassofdehydroabietylaminederivatives AT chaoxiangliu synthesisantitumoranddnacleavageactivitiesofanovelclassofdehydroabietylaminederivatives
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Synthesis, antitumor and DNA cleavage activities of a novel class of dehydroabietylamine derivatives

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