Neuroinflammation and brain functional disconnection in Alzheimer's disease

Neuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analys...

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Main Authors: Francesca eBaglio, Marina eSaresella, Maria Giulia Preti, Monia eCabinio, Ludovica eGriffanti, Ivana eMarventano, Federica ePiancone, Elena eCalabrese, Raffaello eNemni, Mario eClerici
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00081/full
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spelling doaj-ecdb996e200e497890dc878c4768c9912020-11-25T01:08:26ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-11-01510.3389/fnagi.2013.0008170201Neuroinflammation and brain functional disconnection in Alzheimer's diseaseFrancesca eBaglio0Marina eSaresella1Maria Giulia Preti2Maria Giulia Preti3Monia eCabinio4Monia eCabinio5Ludovica eGriffanti6Ludovica eGriffanti7Ivana eMarventano8Federica ePiancone9Elena eCalabrese10Raffaello eNemni11Raffaello eNemni12Mario eClerici13Mario eClerici14IRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiPolitecnico di MilanoIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoIRCCS, Fondazione Don Carlo GnocchiPolitecnico di MilanoIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoNeuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analyses in people with amnestic Mild Cognitive Impairment (aMCI) and AD. DTI-Analyses focused on corpus callosum (CC). We found that frontal CC regions were preserved with respect to the posterior ones in aMCI; in these individuals significant correlations were seen between DTI-derived metrics in frontal-parietal CC areas and Aβ42-stimulated BDNF-producing CD4+ T lymphocytes and PDL-1-expressing CD14+ cells. These associations were lost in AD where DTI data involving the same CC areas correlated instead with Aβ42-stimulated IL-21 producing CD4+ T lymphocytes. Higher susceptibility to PDL-1-mediated apoptosis of Aβ42-specific lymphocytes and BDNF-associated survival of existing neurons could contribute to the relative CC structure preservation seen in aMCI. These potentially protective mechanisms are lost in frank AD, when severe alterations in the CC are mirrored in peripheral blood by proinflammatory cytokines-producing T cells. Monitoring of immune cells in peripheral blood could have a prognostic value in AD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00081/fullNeuroinflammationimmunologymild cognitive impairment (MCI)Alzheimer’s disease (AD)magnetic resonance imaging (MRI)Diffusion tensor imaging (DTI)
collection DOAJ
language English
format Article
sources DOAJ
author Francesca eBaglio
Marina eSaresella
Maria Giulia Preti
Maria Giulia Preti
Monia eCabinio
Monia eCabinio
Ludovica eGriffanti
Ludovica eGriffanti
Ivana eMarventano
Federica ePiancone
Elena eCalabrese
Raffaello eNemni
Raffaello eNemni
Mario eClerici
Mario eClerici
spellingShingle Francesca eBaglio
Marina eSaresella
Maria Giulia Preti
Maria Giulia Preti
Monia eCabinio
Monia eCabinio
Ludovica eGriffanti
Ludovica eGriffanti
Ivana eMarventano
Federica ePiancone
Elena eCalabrese
Raffaello eNemni
Raffaello eNemni
Mario eClerici
Mario eClerici
Neuroinflammation and brain functional disconnection in Alzheimer's disease
Frontiers in Aging Neuroscience
Neuroinflammation
immunology
mild cognitive impairment (MCI)
Alzheimer’s disease (AD)
magnetic resonance imaging (MRI)
Diffusion tensor imaging (DTI)
author_facet Francesca eBaglio
Marina eSaresella
Maria Giulia Preti
Maria Giulia Preti
Monia eCabinio
Monia eCabinio
Ludovica eGriffanti
Ludovica eGriffanti
Ivana eMarventano
Federica ePiancone
Elena eCalabrese
Raffaello eNemni
Raffaello eNemni
Mario eClerici
Mario eClerici
author_sort Francesca eBaglio
title Neuroinflammation and brain functional disconnection in Alzheimer's disease
title_short Neuroinflammation and brain functional disconnection in Alzheimer's disease
title_full Neuroinflammation and brain functional disconnection in Alzheimer's disease
title_fullStr Neuroinflammation and brain functional disconnection in Alzheimer's disease
title_full_unstemmed Neuroinflammation and brain functional disconnection in Alzheimer's disease
title_sort neuroinflammation and brain functional disconnection in alzheimer's disease
publisher Frontiers Media S.A.
series Frontiers in Aging Neuroscience
issn 1663-4365
publishDate 2013-11-01
description Neuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analyses in people with amnestic Mild Cognitive Impairment (aMCI) and AD. DTI-Analyses focused on corpus callosum (CC). We found that frontal CC regions were preserved with respect to the posterior ones in aMCI; in these individuals significant correlations were seen between DTI-derived metrics in frontal-parietal CC areas and Aβ42-stimulated BDNF-producing CD4+ T lymphocytes and PDL-1-expressing CD14+ cells. These associations were lost in AD where DTI data involving the same CC areas correlated instead with Aβ42-stimulated IL-21 producing CD4+ T lymphocytes. Higher susceptibility to PDL-1-mediated apoptosis of Aβ42-specific lymphocytes and BDNF-associated survival of existing neurons could contribute to the relative CC structure preservation seen in aMCI. These potentially protective mechanisms are lost in frank AD, when severe alterations in the CC are mirrored in peripheral blood by proinflammatory cytokines-producing T cells. Monitoring of immune cells in peripheral blood could have a prognostic value in AD.
topic Neuroinflammation
immunology
mild cognitive impairment (MCI)
Alzheimer’s disease (AD)
magnetic resonance imaging (MRI)
Diffusion tensor imaging (DTI)
url http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00081/full
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