Neuroinflammation and brain functional disconnection in Alzheimer's disease
Neuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analys...
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doaj-ecdb996e200e497890dc878c4768c9912020-11-25T01:08:26ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-11-01510.3389/fnagi.2013.0008170201Neuroinflammation and brain functional disconnection in Alzheimer's diseaseFrancesca eBaglio0Marina eSaresella1Maria Giulia Preti2Maria Giulia Preti3Monia eCabinio4Monia eCabinio5Ludovica eGriffanti6Ludovica eGriffanti7Ivana eMarventano8Federica ePiancone9Elena eCalabrese10Raffaello eNemni11Raffaello eNemni12Mario eClerici13Mario eClerici14IRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiPolitecnico di MilanoIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoIRCCS, Fondazione Don Carlo GnocchiPolitecnico di MilanoIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoIRCCS, Fondazione Don Carlo GnocchiUniversità degli Studi di MilanoNeuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analyses in people with amnestic Mild Cognitive Impairment (aMCI) and AD. DTI-Analyses focused on corpus callosum (CC). We found that frontal CC regions were preserved with respect to the posterior ones in aMCI; in these individuals significant correlations were seen between DTI-derived metrics in frontal-parietal CC areas and Aβ42-stimulated BDNF-producing CD4+ T lymphocytes and PDL-1-expressing CD14+ cells. These associations were lost in AD where DTI data involving the same CC areas correlated instead with Aβ42-stimulated IL-21 producing CD4+ T lymphocytes. Higher susceptibility to PDL-1-mediated apoptosis of Aβ42-specific lymphocytes and BDNF-associated survival of existing neurons could contribute to the relative CC structure preservation seen in aMCI. These potentially protective mechanisms are lost in frank AD, when severe alterations in the CC are mirrored in peripheral blood by proinflammatory cytokines-producing T cells. Monitoring of immune cells in peripheral blood could have a prognostic value in AD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00081/fullNeuroinflammationimmunologymild cognitive impairment (MCI)Alzheimer’s disease (AD)magnetic resonance imaging (MRI)Diffusion tensor imaging (DTI) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca eBaglio Marina eSaresella Maria Giulia Preti Maria Giulia Preti Monia eCabinio Monia eCabinio Ludovica eGriffanti Ludovica eGriffanti Ivana eMarventano Federica ePiancone Elena eCalabrese Raffaello eNemni Raffaello eNemni Mario eClerici Mario eClerici |
spellingShingle |
Francesca eBaglio Marina eSaresella Maria Giulia Preti Maria Giulia Preti Monia eCabinio Monia eCabinio Ludovica eGriffanti Ludovica eGriffanti Ivana eMarventano Federica ePiancone Elena eCalabrese Raffaello eNemni Raffaello eNemni Mario eClerici Mario eClerici Neuroinflammation and brain functional disconnection in Alzheimer's disease Frontiers in Aging Neuroscience Neuroinflammation immunology mild cognitive impairment (MCI) Alzheimer’s disease (AD) magnetic resonance imaging (MRI) Diffusion tensor imaging (DTI) |
author_facet |
Francesca eBaglio Marina eSaresella Maria Giulia Preti Maria Giulia Preti Monia eCabinio Monia eCabinio Ludovica eGriffanti Ludovica eGriffanti Ivana eMarventano Federica ePiancone Elena eCalabrese Raffaello eNemni Raffaello eNemni Mario eClerici Mario eClerici |
author_sort |
Francesca eBaglio |
title |
Neuroinflammation and brain functional disconnection in Alzheimer's disease |
title_short |
Neuroinflammation and brain functional disconnection in Alzheimer's disease |
title_full |
Neuroinflammation and brain functional disconnection in Alzheimer's disease |
title_fullStr |
Neuroinflammation and brain functional disconnection in Alzheimer's disease |
title_full_unstemmed |
Neuroinflammation and brain functional disconnection in Alzheimer's disease |
title_sort |
neuroinflammation and brain functional disconnection in alzheimer's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2013-11-01 |
description |
Neuroinflammation and brain functional disconnection result from β-amyloid (Aβ) accumulation and play fundamental roles in the pathogenesis of Alzheimer’s disease (AD). We investigated possible correlations between these two AD-associated phenomena using DTI-based tractography and immunologic analyses in people with amnestic Mild Cognitive Impairment (aMCI) and AD. DTI-Analyses focused on corpus callosum (CC). We found that frontal CC regions were preserved with respect to the posterior ones in aMCI; in these individuals significant correlations were seen between DTI-derived metrics in frontal-parietal CC areas and Aβ42-stimulated BDNF-producing CD4+ T lymphocytes and PDL-1-expressing CD14+ cells. These associations were lost in AD where DTI data involving the same CC areas correlated instead with Aβ42-stimulated IL-21 producing CD4+ T lymphocytes. Higher susceptibility to PDL-1-mediated apoptosis of Aβ42-specific lymphocytes and BDNF-associated survival of existing neurons could contribute to the relative CC structure preservation seen in aMCI. These potentially protective mechanisms are lost in frank AD, when severe alterations in the CC are mirrored in peripheral blood by proinflammatory cytokines-producing T cells. Monitoring of immune cells in peripheral blood could have a prognostic value in AD. |
topic |
Neuroinflammation immunology mild cognitive impairment (MCI) Alzheimer’s disease (AD) magnetic resonance imaging (MRI) Diffusion tensor imaging (DTI) |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00081/full |
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