Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

Besides being a neuronal fuel, L-lactate is also a signal in the brain. Whether extracellular L-lactate affects brain metabolism, in particular astrocytes, abundant neuroglial cells, which produce L-lactate in aerobic glycolysis, is unclear. Recent studies suggested that astrocytes express low level...

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Bibliographic Details
Main Authors: Nina Vardjan, Helena H. Chowdhury, Anemari Horvat, Jelena Velebit, Maja Malnar, Marko Muhič, Marko Kreft, Špela G. Krivec, Saša T. Bobnar, Katarina Miš, Sergej Pirkmajer, Stefan Offermanns, Gjermund Henriksen, Jon Storm-Mathisen, Linda H. Bergersen, Robert Zorec
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
astrocytes
aerobic glycolysis
L-lactate receptor
cAMP
L-lactate
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00148/full

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