Autosomal dominant Alzheimer disease: A unique resource to study CSF biomarker changes in preclinical AD

Autosomal dominant Alzheimer disease: A unique resource to study CSF biomarker changes in preclinical AD

Our understanding of the pathogenesis of Alzheimer disease (AD) has been greatly influenced by investigation of rare families with autosomal dominant mutations that cause early onset AD. Mutations in the genes coding for Amyloid Precursor Protein (APP), Presenilin 1 (PSEN-1) and Presenilin 2 (PSEN-...

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Bibliographic Details
Main Authors: Suzanne Elizabeth Schindler, Anne M Fagan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neurology
Subjects:
Alzheimer Disease
Cerebrospinal Fluid
biomarkers
familial
autosomal dominant
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00142/full

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