α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants

α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants

The increase in confirmed COVID-19 cases and SARS-CoV-2 variants calls for the development of safe and broad cross-protective vaccines. The RBD of the spike protein was considered to be a safe and effective candidate antigen. However, the low immunogenicity limited its application in vaccine develop...

Full description

Bibliographic Details
Main Authors: Jintao Zou, Haiming Jing, Xiaoli Zhang, Yiheng Liu, Zhuo Zhao, Lianli Duan, Yue Yuan, Zhifu Chen, Qiang Gou, Qingshan Xiong, Sisi Li, Feng Yang, Hao Zeng, Quanming Zou, Jinyong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
subunit vaccine
mHla-RBD
oligomerization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.757691/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.757691/full

Similar Items