Strategies for Enhancing Polyester-Based Materials for Bone Fixation Applications

• Main Authors: Raasti Naseem, Charalampos Tzivelekis, Matthew J. German, Piergiorgio Gentile, Ana M. Ferreira, Kenny Dalgarno
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Molecules
• Subjects: biomaterials; polyesters; polymer blends; copolymers; biodegradable materials; bone regeneration
• Online Access: https://www.mdpi.com/1420-3049/26/4/992

Polyester-based materials are established options, regarding the manufacturing of bone fixation devices and devices in routine clinical use. This paper reviews the approaches researchers have taken to develop these materials to improve their mechanical and biological performances. Polymer blending, copolymerisation, and the use of particulates and fibre bioceramic materials to make composite materials and surface modifications have all been studied. Polymer blending, copolymerisation, and particulate composite approaches have been adopted commercially, with the primary focus on influencing the in vivo degradation rate. There are emerging opportunities in novel polymer blends and nanoscale particulate systems, to tune bulk properties, and, in terms of surface functionalisation, to optimise the initial interaction of devices with the implanted environment, offering the potential to improve the clinical performances of fracture fixation devices.