COMPARATIVE EFFECTIVENESS PIPOFEZINE, TIANEPTINE AND CHLORPROTHIXENE IN PATIENTS WITH ATTENTION DEFICIT DISORDER , AND HYPERTENSION: AN OPEN NON-RANDOMIZED STUDY

• Main Author: V. V. Glushchenko
• Format: Article
• Language: English
• Published: Stolichnaya Izdatelskaya Kompaniya 2015-12-01
• Series: Racionalʹnaâ Farmakoterapiâ v Kardiologii
• Subjects: attention deficit hyperactivity disorder; arterial hypertension; electroencephalography
• Online Access: https://www.rpcardio.com/jour/article/view/465
• ISSN: 1819-6446; 2225-3653

Aim. To evaluate the influence of pipofezine, tianeptine and chlorprothixene on blood pressure (BP) level and neuropsychological performance in patients with attention deficit hyperactivity disorder (ADHD) and arterial hypertension (HT). Material and methods. Young males with ADHD and HT (n=58) were included into the study. Patients were split into three treatment groups: group 1 (n=19) received pipofezine 50 mg/day, group 2 (n=20) — tianeptine 25 mg/day , group 3 (n=19) — chlorprothixene 50 mg/day. Clinicopsychopathologic and neurophysiological findings were evaluated at baseline and after 4 weeks of treatment. BP self-monitoring, analysis of psychiatric disorders severity with Brief Psychiatric Rating Scale, electroencephalography (EEG) were performed. Results. The positive dynamics of disregulatory-motor hyperactivity , subjective-cognitive and emotional-vegetative components of ADHD was observed. The positive dynamics of neurophysiological parameters (increase in EEG frequencies index) in groups 1 and 2 (from 0.37±0.05 to 0.54±0.07 and 0.38±0.06 to 0.50±0.05, respectively , p<0.05 for both) was also found. There were no significant effects of the study drugs on BP levels in patients of all groups (p>0.05). Conclusion. Four-week usage of the study drugs in adolescents with ADHD and HT had no significant effect on BP levels. Pipofezine and tianeptine showed more pronounced improvement of clinicopsychiatric and neuropsychological performance in comparison with chlorprothixene in patients with ADHD.