A Matricryptic Conformation of the Integrin-Binding Domain of Fibronectin Regulates Platelet-Derived Growth Factor-Induced Intracellular Calcium Release

A Matricryptic Conformation of the Integrin-Binding Domain of Fibronectin Regulates Platelet-Derived Growth Factor-Induced Intracellular Calcium Release

Platelet-derived growth factor (PDGF) signaling is dysregulated in a wide variety of diseases, making PDGF an attractive therapeutic target. However, PDGF also affects numerous signaling cascades essential for tissue homeostasis, limiting the development of PDGF-based therapies that lack adverse sid...

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Bibliographic Details
Main Authors: Christopher S. Farrar, Geoffrey T. Rouin, Benjamin L. Miller, Carol H. Raeman, Nancie A. Mooney, Denise C. Hocking
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
extracellular matrix
calcium
phosphoinositide 3-kinase
growth factors
integrin
molecular dynamics simulations
Online Access:https://www.mdpi.com/2073-4409/8/11/1351

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