An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain

An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain

Pain is a major symptom of bone metastases from advanced cancer and represents a clinical challenge to treat effectively. Basic neurobiology in preclinical animal models implicates enhanced sensory processing in the central nervous system, acting through N-methyl-D-aspartate (NMDA) glutamate recepto...

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Bibliographic Details
Main Authors: Sarah Danson, Matthew R Mulvey, Lesley Turner, Janet Horsman, KJane Escott, Robert E Coleman, Sam H Ahmedzai, Michael I Bennett, David Andrew
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Bone Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137419301691

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