HIV-1 infected patients with suppressed plasma viremia on treatment have pro-inflammatory HDL

• Main Authors: Navab Kaveh, Currier Judith S, Yang Otto O, Kelesidis Theodoros, Fogelman Alan M, Navab Mohamad
• Format: Article
• Language: English
• Published: BMC 2011-02-01
• Series: Lipids in Health and Disease
• Online Access: http://www.lipidworld.com/content/10/1/35

<p>Abstract</p> <p>Background</p> <p>The role of pro-inflammatory lipids in systemic immune activation in HIV infection remains largely unknown. We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons.</p> <p>Methods</p> <p>Plasma was obtained from 10 HIV-1-infected individuals on combination antiretroviral therapy with suppressed viremia and was incubated with the apoA-I mimetic peptide L-4F or sham-treated prior to isolation of HDL. The HDL that was isolated from each sample was tested for its ability to inhibit LDL-induced MCP-1 production in cultures of human aortic endothelial cells.</p> <p>Results</p> <p>We found in a small pilot study of HIV-1-infected individuals with suppressed viremia on combination antiretroviral therapy that oxidative stress and inflammation in HIV-1 are associated with a marked reduction of HDL antioxidant/anti-inflammatory activities. In vitro, these abnormalities were significantly improved by treatment with the apoA-1 mimetic peptide, 4F.</p> <p>Conclusions</p> <p>These preliminary observations suggest that the anti-inflammatory properties of HDL are defective in HIV-1-infected persons despite treatment that is considered to be virologically successful.</p>