Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.
Bibliographic Details
| Main Authors: |
Akihisa Kato,
Shungo Adachi,
Shuichi Kawano,
Kousuke Takeshima,
Mizuki Watanabe,
Shinobu Kitazume,
Ryota Sato,
Hideo Kusano,
Naoto Koyanagi,
Yuhei Maruzuru,
Jun Arii,
Tomohisa Hatta,
Tohru Natsume,
Yasushi Kawaguchi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18718-9
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