Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.

Bibliographic Details
Main Authors: Akihisa Kato, Shungo Adachi, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii, Tomohisa Hatta, Tohru Natsume, Yasushi Kawaguchi
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18718-9

Internet

https://doi.org/10.1038/s41467-020-18718-9

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