First CTX-M type ß–lactamase-Producing and Ciprofloxacin Resistant Salmonella Infection Acquired by a Child in IRAN

• Main Authors: Farzaneh Firoozeh, Fereshteh Shahcheraghi, Taghi Zahraei-Salehi, Mohammad Mehdi Aslani, Reihaneh Banisaeed
• Format: Article
• Language: English
• Published: Alborz University of Medical Sciences 2013-11-01
• Series: International Journal of Enteric Pathogens
• Subjects: Ciprofloxacin; blaCTX-M; Extended Spectrum β-lactamase; Multidrug Resistance; Salmonella Enteritidis
• Online Access: http://enterpathog.abzums.ac.ir/PDF/ijep-1-13774.pdf
• ISSN: 2345-3362; 2322-5866

The frequency of multidrug-resistance (MDR) among Salmonella isolates has increased dramatically. Here we report the first case of CTX-M type ß–lactamase producing ciprofloxacin-resistant Salmonella infection as a child in Iran. Antimicrobial resistance profile was determine daccording to the Clinical and Laboratory Standards Institute. A double disk synergy test was used in the production of extended-spectrum β-lactamases (ESBLs). PCR assays were carried out to detect blaTEM, blaSHV and blaCTX-M beta lactamase genes. The presence of class 1 integrons was investigated by PCR assays. The Salmonella Enteritidis isolate from the child was ciprofloxacin and extended-spectrum cephalosporins resistant and found to carry the blaCTX-M beta-lactamase gene and class 1 integrons, suggests that antimicrobial resistance determinants may be located on the same genetic unit of the class 1 integrons identified here. Resistance to ciprofloxacin and extended spectrumcephalosporins, the drugs of choice for treating invasive salmonellosis, especially in children is a public health problem.