Tumor Progression and Oncogene Addiction in a PDGF-B-Induced Model of Gliomagenesis

Tumor Progression and Oncogene Addiction in a PDGF-B-Induced Model of Gliomagenesis

Platelet-derived growth factor B (PDGF-B) overexpression induces gliomas of different grades from murine embryonic neural progenitors. For the first time, we formally demonstrated that PDGF-B-induced neoplasms undergo progression from nontumorigenic low-grade tumors toward highly malignant forms. T...

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Bibliographic Details
Main Authors: Filippo Calzolari, Irene Appolloni, Evelina Tutucci, Sara Caviglia, Marta Terrile, Giorgio Corte, Paolo Malatesta
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800826

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