iPNHOT: a knowledge-based approach for identifying protein-nucleic acid interaction hot spots

iPNHOT: a knowledge-based approach for identifying protein-nucleic acid interaction hot spots

Abstract Background The interaction between proteins and nucleic acids plays pivotal roles in various biological processes such as transcription, translation, and gene regulation. Hot spots are a small set of residues that contribute most to the binding affinity of a protein-nucleic acid interaction...

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Bibliographic Details
Main Authors: Xiaolei Zhu, Ling Liu, Jingjing He, Ting Fang, Yi Xiong, Julie C. Mitchell
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Bioinformatics
Subjects:
Protein-nucleic acid interaction
Hot spots
Feature selection
Electrostatic potential
Support vector machine
Online Access:http://link.springer.com/article/10.1186/s12859-020-03636-w

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http://link.springer.com/article/10.1186/s12859-020-03636-w

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