Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Mouse incisor growth depends upon mesenchymal stromal cells (MSCs) and transit amplifying cells (TACs). Here the authors describe a distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts.

Bibliographic Details
Main Authors: Jemma Victoria Walker, Heng Zhuang, Donald Singer, Charlotte Sara Illsley, Wai Ling Kok, Kishor K. Sivaraj, Yan Gao, Chloe Bolton, Yuying Liu, Mengyuan Zhao, Portia Rebecca Clare Grayson, Shuang Wang, Jana Karbanová, Tim Lee, Stefano Ardu, Qingguo Lai, Jihui Liu, Moustapha Kassem, Shuo Chen, Kai Yang, Yuxing Bai, Christopher Tredwin, Alexander C. Zambon, Denis Corbeil, Ralf Adams, Basem M. Abdallah, Bing Hu
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11611-0
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spelling doaj-ec84db5984804a3e870c585b51600d3f2021-05-11T11:57:11ZengNature Publishing GroupNature Communications2041-17232019-08-0110111810.1038/s41467-019-11611-0Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activationJemma Victoria Walker0Heng Zhuang1Donald Singer2Charlotte Sara Illsley3Wai Ling Kok4Kishor K. Sivaraj5Yan Gao6Chloe Bolton7Yuying Liu8Mengyuan Zhao9Portia Rebecca Clare Grayson10Shuang Wang11Jana Karbanová12Tim Lee13Stefano Ardu14Qingguo Lai15Jihui Liu16Moustapha Kassem17Shuo Chen18Kai Yang19Yuxing Bai20Christopher Tredwin21Alexander C. Zambon22Denis Corbeil23Ralf Adams24Basem M. Abdallah25Bing Hu26Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthDepartment of Cariology, Endodontology and Operative Dentistry, Peking University School and Hospital of StomatologyStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthMax Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of MedicineStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthInstitute of Dental Research, Beijing Stomatological Hospital, Capital Medical UniversityStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthFaculty of Dentistry, National University of SingaporeTissue Engineering Laboratories (BIOTEC), Technische Universität DresdenDepartment of Biopharmaceutical Sciences, Keck Graduate InstituteClinique Universitaire de Médecine Dentaire, Université de GenèveDepartment of Oral and Maxillofacial Surgery, the Second Hospital of Shandong UniversityDepartment of Orthodontics, Shenyang Stomatological HospitalMolecular Endocrinology Lab (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern DenmarkDepartment of Developmental Dentistry, Dental School, The University of Texas Health Science Center at San AntonioDepartment of Orthodontics, School of Stomatology, Capital Medical UniversityDepartment of Orthodontics, School of Stomatology, Capital Medical UniversityStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthDepartment of Biopharmaceutical Sciences, Keck Graduate InstituteTissue Engineering Laboratories (BIOTEC), Technische Universität DresdenMax Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of MedicineMolecular Endocrinology Lab (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern DenmarkStem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of PlymouthMouse incisor growth depends upon mesenchymal stromal cells (MSCs) and transit amplifying cells (TACs). Here the authors describe a distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts.https://doi.org/10.1038/s41467-019-11611-0
collection DOAJ
language English
format Article
sources DOAJ
author Jemma Victoria Walker
Heng Zhuang
Donald Singer
Charlotte Sara Illsley
Wai Ling Kok
Kishor K. Sivaraj
Yan Gao
Chloe Bolton
Yuying Liu
Mengyuan Zhao
Portia Rebecca Clare Grayson
Shuang Wang
Jana Karbanová
Tim Lee
Stefano Ardu
Qingguo Lai
Jihui Liu
Moustapha Kassem
Shuo Chen
Kai Yang
Yuxing Bai
Christopher Tredwin
Alexander C. Zambon
Denis Corbeil
Ralf Adams
Basem M. Abdallah
Bing Hu
spellingShingle Jemma Victoria Walker
Heng Zhuang
Donald Singer
Charlotte Sara Illsley
Wai Ling Kok
Kishor K. Sivaraj
Yan Gao
Chloe Bolton
Yuying Liu
Mengyuan Zhao
Portia Rebecca Clare Grayson
Shuang Wang
Jana Karbanová
Tim Lee
Stefano Ardu
Qingguo Lai
Jihui Liu
Moustapha Kassem
Shuo Chen
Kai Yang
Yuxing Bai
Christopher Tredwin
Alexander C. Zambon
Denis Corbeil
Ralf Adams
Basem M. Abdallah
Bing Hu
Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
Nature Communications
author_facet Jemma Victoria Walker
Heng Zhuang
Donald Singer
Charlotte Sara Illsley
Wai Ling Kok
Kishor K. Sivaraj
Yan Gao
Chloe Bolton
Yuying Liu
Mengyuan Zhao
Portia Rebecca Clare Grayson
Shuang Wang
Jana Karbanová
Tim Lee
Stefano Ardu
Qingguo Lai
Jihui Liu
Moustapha Kassem
Shuo Chen
Kai Yang
Yuxing Bai
Christopher Tredwin
Alexander C. Zambon
Denis Corbeil
Ralf Adams
Basem M. Abdallah
Bing Hu
author_sort Jemma Victoria Walker
title Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
title_short Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
title_full Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
title_fullStr Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
title_full_unstemmed Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
title_sort transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Mouse incisor growth depends upon mesenchymal stromal cells (MSCs) and transit amplifying cells (TACs). Here the authors describe a distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts.
url https://doi.org/10.1038/s41467-019-11611-0
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