Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates

Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i>. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. T...

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Main Authors:	Solomon Abrha, Andrew Bartholomaeus, Wubshet Tesfaye, Jackson Thomas
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Antibiotics
Subjects:	animal models hamsters impetigo in vivo evaluation mice review
Online Access:	https://www.mdpi.com/2079-6382/9/10/694

id	doaj-ec81fa382e1f456f8b7efbd21cfd3853
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spelling	doaj-ec81fa382e1f456f8b7efbd21cfd38532020-11-25T03:58:29ZengMDPI AGAntibiotics2079-63822020-10-01969469410.3390/antibiotics9100694Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug CandidatesSolomon Abrha0Andrew Bartholomaeus1Wubshet Tesfaye2Jackson Thomas3Faculty of Health, University of Canberra, Bruce, Australian Capital Territory 2617, Canberra, AustraliaFaculty of Health, University of Canberra, Bruce, Australian Capital Territory 2617, Canberra, AustraliaFaculty of Health, University of Canberra, Bruce, Australian Capital Territory 2617, Canberra, AustraliaFaculty of Health, University of Canberra, Bruce, Australian Capital Territory 2617, Canberra, AustraliaImpetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i>. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. The efficacy of potential new antimicrobial compounds is first tested in in vitro studies and, if effective, followed by in vivo studies using animal models and/or humans. Animal models are critical means for investigating potential therapeutics and characterizing their safety profile prior to human trials. Although several reviews of animal models for skin infections have been published, there is a lack of a comprehensive review of animal models simulating impetigo for the selection of therapeutic drug candidates. This review critically examines the existing animal models for impetigo and their feasibility for testing the in vivo efficacy of topical treatments for impetigo and other superficial bacterial skin infections.https://www.mdpi.com/2079-6382/9/10/694animal modelshamstersimpetigoin vivo evaluationmicereview
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Solomon Abrha Andrew Bartholomaeus Wubshet Tesfaye Jackson Thomas
spellingShingle	Solomon Abrha Andrew Bartholomaeus Wubshet Tesfaye Jackson Thomas Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates Antibiotics animal models hamsters impetigo in vivo evaluation mice review
author_facet	Solomon Abrha Andrew Bartholomaeus Wubshet Tesfaye Jackson Thomas
author_sort	Solomon Abrha
title	Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
title_short	Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
title_full	Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
title_fullStr	Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
title_full_unstemmed	Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates
title_sort	impetigo animal models: a review of their feasibility and clinical utility for therapeutic appraisal of investigational drug candidates
publisher	MDPI AG
series	Antibiotics
issn	2079-6382
publishDate	2020-10-01
description	Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i>. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. The efficacy of potential new antimicrobial compounds is first tested in in vitro studies and, if effective, followed by in vivo studies using animal models and/or humans. Animal models are critical means for investigating potential therapeutics and characterizing their safety profile prior to human trials. Although several reviews of animal models for skin infections have been published, there is a lack of a comprehensive review of animal models simulating impetigo for the selection of therapeutic drug candidates. This review critically examines the existing animal models for impetigo and their feasibility for testing the in vivo efficacy of topical treatments for impetigo and other superficial bacterial skin infections.
topic	animal models hamsters impetigo in vivo evaluation mice review
url	https://www.mdpi.com/2079-6382/9/10/694
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Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates

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