Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism

• Main Authors: Ming-Heng Tsai, Yueh-Ting Chiu, Darien Zhing-Herr Chan, Cheng-Hao Wen, Shih-Han Syu, Huai-En Lu, Chi-Ying F. Huang, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Ching-Ying Huang, Yu-Feng Hu, Patrick C.H. Hsieh, Shih-Ann Chen
• Format: Article
• Language: English
• Published: Elsevier 2021-07-01
• Series: Stem Cell Research
• Online Access: http://www.sciencedirect.com/science/article/pii/S1873506121002622

ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.