RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma

RECQ1 Promotes Stress Resistance and DNA Replication Progression Through PARP1 Signaling Pathway in Glioblastoma

Glioblastoma (GBM) is the most common aggressive primary malignant brain tumor, and patients with GBM have a median survival of 20 months. Clinical therapy resistance is a challenging barrier to overcome. Tumor genome stability maintenance during DNA replication, especially the ability to respond to...

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Bibliographic Details
Main Authors: Jing Zhang, Hao Lian, Kui Chen, Ying Pang, Mu Chen, Bingsong Huang, Lei Zhu, Siyi Xu, Min Liu, Chunlong Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
genomic stability
drug resistance
DNA replication stress
fork reversal
RECQ1
PARP1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.714868/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.714868/full

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