Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1

Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1

Abstract Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarcinoma (LUAD) and 497 patients with squamous cell carcinoma (LUSC) from The Canc...

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Bibliographic Details
Main Authors: Liang Liu, Jimmy Ruiz, Stacey S. O’Neill, Stefan C. Grant, W. Jeffrey Petty, Meng Yang, Kexin Chen, Umit Topaloglu, Boris Pasche, Wei Zhang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Molecular Cancer
Subjects:
POLE mutation
PD-L1 expression
Lung cancer adenocarcinoma
Lung cancer squamous cell carcinoma
Overall survival
Non-small cell lung cancer
Online Access:http://link.springer.com/article/10.1186/s12943-018-0832-y

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