Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure

Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure

Clozapine (CLO) remains an ultimate option for patients with treatment resistant schizophrenia. However, the atypical antipsychotic is often associated with serious metabolic side effects, such as dyslipidemia. Hepatic sterol regulatory element-binding proteins (SREBPs) are central in the allosteric...

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Bibliographic Details
Main Authors: Zhen Liu, Changmeng Cui, Pengfei Xu, Ruili Dang, Hualin Cai, Dehua Liao, Mengqi Yang, Qingyan Feng, Xin Yan, Pei Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neuroscience
Subjects:
curcumin
clozapine
AMPK
SREBP
dyslipidemia
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00558/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00558/full

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