Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

Cranial sutures separate the skull bones and house stem cells for bone growth and repair. In Saethre-Chotzen syndrome, mutations in TCF12 or TWIST1 ablate a specific suture, the coronal. This suture forms at a neural-crest/mesoderm interface in mammals and a mesoderm/mesoderm interface in zebrafish....

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Bibliographic Details
Main Authors: Camilla S Teng, Man-chun Ting, D'Juan T Farmer, Mia Brockop, Robert E Maxson, J Gage Crump
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
Saethre-Chotzen Syndrome
Twist1
Tcf12
coronal suture
craniosynostosis
skull bones
Online Access:https://elifesciences.org/articles/37024

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