The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis

Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an imp...

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Main Authors:	Emer P. Reeves, David A. Bergin, Michelle A. Murray, Noel G. McElvaney
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1100/tsw.2011.81

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spelling	doaj-ec525f7284384e4abbcc98cd2e431cc12020-11-25T01:14:20ZengHindawi LimitedThe Scientific World Journal1537-744X2011-01-011195997110.1100/tsw.2011.81The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic FibrosisEmer P. Reeves0David A. Bergin1Michelle A. Murray2Noel G. McElvaney3Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandIndividuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.http://dx.doi.org/10.1100/tsw.2011.81
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney
spellingShingle	Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis The Scientific World Journal
author_facet	Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney
author_sort	Emer P. Reeves
title	The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
title_short	The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
title_full	The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
title_fullStr	The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
title_full_unstemmed	The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
title_sort	involvement of glycosaminoglycans in airway disease associated with cystic fibrosis
publisher	Hindawi Limited
series	The Scientific World Journal
issn	1537-744X
publishDate	2011-01-01
description	Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.
url	http://dx.doi.org/10.1100/tsw.2011.81
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The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis

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