Heterologous Expression of a VioA Variant Activates Cryptic Compounds in a Marine-Derived Brevibacterium Strain

Heterologous Expression of a VioA Variant Activates Cryptic Compounds in a Marine-Derived Brevibacterium Strain

A new 14-membered homodimeric macrodiolide, brevidiolide (3), along with four known aromatic compounds (1, 2, 4 and 5) were obtained by heterologous expression of the recombinant plasmid pWLI823 expressing the G231L variant of VioA in the marine-derived Brevibacterium sp. 7002-073. The structures of...

Full description

Bibliographic Details
Main Authors: Xiao Han, Lukuan Hou, Jing Hou, Yongyu Zhang, Huayue Li, Wenli Li
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Marine Drugs
Subjects:
heterologous expression
recombinant
Brevibacterium
macrodiolide
antibacterial
Online Access:http://www.mdpi.com/1660-3397/16/6/191

Internet

http://www.mdpi.com/1660-3397/16/6/191

Similar Items