Resistin, a Novel Host Defense Peptide of Innate Immunity
Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory role in many chronic inflammatory diseases, metab...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.699807/full |
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doaj-ec4a627f328742c88de0540166024cfc2021-06-18T17:11:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.699807699807Resistin, a Novel Host Defense Peptide of Innate ImmunityYanran Li0Qiyuan Yang1Dongjie Cai2Hongrui Guo3Jing Fang4Hengmin Cui5Liping Gou6Junliang Deng7Zhisheng Wang8Zhicai Zuo9Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaResistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory role in many chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that resistin functions as a host defense peptide of innate immunity, in terms of its wide-spectrum anti-microbial activity, modulation of immunity, and limitation of microbial product-induced inflammation. To date, the understanding of resistin participating in host defense mechanism is still limited. The review aims to summarize current knowledge about the biological properties, functions, and related mechanisms of resistin in host defense, which provides new insights into the pleiotropic biological function of resistin and yields promising strategies for developing new antimicrobial therapeutic agents.https://www.frontiersin.org/articles/10.3389/fimmu.2021.699807/fullresistinhost defense peptideanti-bacteriaanti-inflammationimmunomodulationinnate immunity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yanran Li Qiyuan Yang Dongjie Cai Hongrui Guo Jing Fang Hengmin Cui Liping Gou Junliang Deng Zhisheng Wang Zhicai Zuo |
| spellingShingle |
Yanran Li Qiyuan Yang Dongjie Cai Hongrui Guo Jing Fang Hengmin Cui Liping Gou Junliang Deng Zhisheng Wang Zhicai Zuo Resistin, a Novel Host Defense Peptide of Innate Immunity Frontiers in Immunology resistin host defense peptide anti-bacteria anti-inflammation immunomodulation innate immunity |
| author_facet |
Yanran Li Qiyuan Yang Dongjie Cai Hongrui Guo Jing Fang Hengmin Cui Liping Gou Junliang Deng Zhisheng Wang Zhicai Zuo |
| author_sort |
Yanran Li |
| title |
Resistin, a Novel Host Defense Peptide of Innate Immunity |
| title_short |
Resistin, a Novel Host Defense Peptide of Innate Immunity |
| title_full |
Resistin, a Novel Host Defense Peptide of Innate Immunity |
| title_fullStr |
Resistin, a Novel Host Defense Peptide of Innate Immunity |
| title_full_unstemmed |
Resistin, a Novel Host Defense Peptide of Innate Immunity |
| title_sort |
resistin, a novel host defense peptide of innate immunity |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2021-06-01 |
| description |
Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory role in many chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that resistin functions as a host defense peptide of innate immunity, in terms of its wide-spectrum anti-microbial activity, modulation of immunity, and limitation of microbial product-induced inflammation. To date, the understanding of resistin participating in host defense mechanism is still limited. The review aims to summarize current knowledge about the biological properties, functions, and related mechanisms of resistin in host defense, which provides new insights into the pleiotropic biological function of resistin and yields promising strategies for developing new antimicrobial therapeutic agents. |
| topic |
resistin host defense peptide anti-bacteria anti-inflammation immunomodulation innate immunity |
| url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.699807/full |
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