Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein gly...

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Main Authors:	Kevin Brown Chandler, Catherine E. Costello, Nader Rahimi
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Cells
Subjects:	glycosylation tumor microenvironment angiogenesis metastasis <i>N</i>-glycosylation <i>O</i>-glycosylation glycosaminoglycans endothelial hypoxia inflammation
Online Access:	https://www.mdpi.com/2073-4409/8/6/544

id	doaj-ec476896d07b4a288d2ee97ce3d68269
record_format	Article
spelling	doaj-ec476896d07b4a288d2ee97ce3d682692020-11-24T21:54:17ZengMDPI AGCells2073-44092019-06-018654410.3390/cells8060544cells8060544Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and MetastasisKevin Brown Chandler0Catherine E. Costello1Nader Rahimi2Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USACenter for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USADepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USAJust as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein glycosylation in tumor cells and associated stromal cells in the tumor microenvironment, which facilitates tumor progression and also modulates a patient’s response to anti-cancer therapeutics. In this review, we highlight the impact of altered glycosylation on angiogenic signaling and endothelial cell adhesion, and the critical consequences of these changes in tumor behavior.https://www.mdpi.com/2073-4409/8/6/544glycosylationtumor microenvironmentangiogenesismetastasis<i>N</i>-glycosylation<i>O</i>-glycosylationglycosaminoglycansendothelialhypoxiainflammation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kevin Brown Chandler Catherine E. Costello Nader Rahimi
spellingShingle	Kevin Brown Chandler Catherine E. Costello Nader Rahimi Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis Cells glycosylation tumor microenvironment angiogenesis metastasis <i>N</i>-glycosylation <i>O</i>-glycosylation glycosaminoglycans endothelial hypoxia inflammation
author_facet	Kevin Brown Chandler Catherine E. Costello Nader Rahimi
author_sort	Kevin Brown Chandler
title	Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_short	Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_full	Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_fullStr	Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_full_unstemmed	Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_sort	glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2019-06-01
description	Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein glycosylation in tumor cells and associated stromal cells in the tumor microenvironment, which facilitates tumor progression and also modulates a patient’s response to anti-cancer therapeutics. In this review, we highlight the impact of altered glycosylation on angiogenic signaling and endothelial cell adhesion, and the critical consequences of these changes in tumor behavior.
topic	glycosylation tumor microenvironment angiogenesis metastasis <i>N</i>-glycosylation <i>O</i>-glycosylation glycosaminoglycans endothelial hypoxia inflammation
url	https://www.mdpi.com/2073-4409/8/6/544
work_keys_str_mv	AT kevinbrownchandler glycosylationinthetumormicroenvironmentimplicationsfortumorangiogenesisandmetastasis AT catherineecostello glycosylationinthetumormicroenvironmentimplicationsfortumorangiogenesisandmetastasis AT naderrahimi glycosylationinthetumormicroenvironmentimplicationsfortumorangiogenesisandmetastasis
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Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis

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