Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure

<p>Abstract</p> <p>Background</p> <p>Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of key components within th...

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Bibliographic Details
Main Authors: Rapp Ulf R, Götz Rudolf, Kramer Boris W
Format: Article
Language:English
Published: BMC 2004-06-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/4/24