Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours
The aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Sta...
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Sciendo
2015-06-01
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| Series: | Bulletin of the Veterinary Institute in Pulawy |
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| Online Access: | https://doi.org/10.1515/bvip-2015-0037 |
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doaj-ec38b10b4e31428da37d060d913e9d3e2021-09-22T06:13:02ZengSciendoBulletin of the Veterinary Institute in Pulawy2300-32352015-06-0159224725310.1515/bvip-2015-0037bvip-2015-0037Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumoursKandefer-Gola Małgorzata0Madej Janusz A.1Dzimira Stanisław2Janus Izabela3Nowak Marcin4Ciaputa Rafał5Department of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences, 50-375Wroclaw, PolandThe aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommendedhttps://doi.org/10.1515/bvip-2015-0037dogsmast cell tumourneoangiogenesislims-1cd31vegf |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kandefer-Gola Małgorzata Madej Janusz A. Dzimira Stanisław Janus Izabela Nowak Marcin Ciaputa Rafał |
| spellingShingle |
Kandefer-Gola Małgorzata Madej Janusz A. Dzimira Stanisław Janus Izabela Nowak Marcin Ciaputa Rafał Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours Bulletin of the Veterinary Institute in Pulawy dogs mast cell tumour neoangiogenesis lims-1 cd31 vegf |
| author_facet |
Kandefer-Gola Małgorzata Madej Janusz A. Dzimira Stanisław Janus Izabela Nowak Marcin Ciaputa Rafał |
| author_sort |
Kandefer-Gola Małgorzata |
| title |
Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| title_short |
Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| title_full |
Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| title_fullStr |
Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| title_full_unstemmed |
Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| title_sort |
immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours |
| publisher |
Sciendo |
| series |
Bulletin of the Veterinary Institute in Pulawy |
| issn |
2300-3235 |
| publishDate |
2015-06-01 |
| description |
The aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommended |
| topic |
dogs mast cell tumour neoangiogenesis lims-1 cd31 vegf |
| url |
https://doi.org/10.1515/bvip-2015-0037 |
| work_keys_str_mv |
AT kandefergolamałgorzata immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours AT madejjanusza immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours AT dzimirastanisław immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours AT janusizabela immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours AT nowakmarcin immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours AT ciaputarafał immunohistochemicalevaluationofneoangiogenesisincaninemastcelltumours |
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1717371887679438848 |