Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma

Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma

Abstract Background Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and metastatic models to study molecular mechanisms of PC and for preclinical...

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Bibliographic Details
Main Authors: Shumei Song, Yan Xu, Longfei Huo, Shuangtao Zhao, Ruiping Wang, Yuan Li, Ailing W. Scott, Melissa Pool Pizzi, Ying Wang, Yibo Fan, Kazuto Harada, Jiankang Jin, Lang Ma, Xiaodan Yao, Namita D. Shanbhag, Qiong Gan, Sinchita Roy-Chowdhuri, Brian D. Badgwell, Zhenning Wang, Linghua Wang, Jaffer A. Ajani
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gastric adenocarcinoma
Peritoneal metastases
Patient-derived cell lines
Patient-derived xenograft, molecular profile
Patient-derived orthotopic model
Online Access:https://doi.org/10.1186/s13046-021-02003-8

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