Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this...

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Main Authors: Yee Ming Khaw, Danish Majid, Sungjong Oh, Eunjoo Kang, Makoto Inoue
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20302-0
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spelling doaj-ec2bf3b33bf84e75958276478c795d7f2021-01-10T12:19:25ZengNature Publishing GroupNature Communications2041-17232021-01-0112111610.1038/s41467-020-20302-0Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signalingYee Ming Khaw0Danish Majid1Sungjong Oh2Eunjoo Kang3Makoto Inoue4University of Illinois at Urbana-Champaign Department of Comparative BiosciencesUniversity of Illinois at Urbana-Champaign Department of Comparative BiosciencesUniversity of Illinois at Urbana-Champaign Department of Comparative BiosciencesUniversity of Illinois at Urbana-Champaign Department of Comparative BiosciencesUniversity of Illinois at Urbana-Champaign Department of Comparative BiosciencesEarly life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this susceptibility.https://doi.org/10.1038/s41467-020-20302-0
collection DOAJ
language English
format Article
sources DOAJ
author Yee Ming Khaw
Danish Majid
Sungjong Oh
Eunjoo Kang
Makoto Inoue
spellingShingle Yee Ming Khaw
Danish Majid
Sungjong Oh
Eunjoo Kang
Makoto Inoue
Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
Nature Communications
author_facet Yee Ming Khaw
Danish Majid
Sungjong Oh
Eunjoo Kang
Makoto Inoue
author_sort Yee Ming Khaw
title Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_short Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_full Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_fullStr Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_full_unstemmed Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_sort early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this susceptibility.
url https://doi.org/10.1038/s41467-020-20302-0
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AT danishmajid earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling
AT sungjongoh earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling
AT eunjookang earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling
AT makotoinoue earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling
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