Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Abstract Background MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1...

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Bibliographic Details
Main Authors: Che-Chung Yeh, Yanying Fan, Yi-Lin Yang, Michael J. Mann
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Biomedical Science
Subjects:
Atrial septal defect
RASopathies
Mitogen-activated protein kinase
MAP kinase phosphatase
Mitogen-activated protein kinase pathway
Online Access:http://link.springer.com/article/10.1186/s12929-017-0392-2

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http://link.springer.com/article/10.1186/s12929-017-0392-2

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