Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors. First, anxiety-like behavior during chronic-mild-stress (CMS) was evaluated in C57BL/6JJmsSlc mice following treatment with CB2R agonist J...

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Bibliographic Details
Main Authors: Hiroki Ishiguro, Yasue Horiuchi, Koichi Tabata, Qing-Rong Liu, Tadao Arinami, Emmanuel S. Onaivi
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
endocannabinoid
cannabinoid CB2 receptor
Cnr2
depression
anxiety
chronic mild stress
neuro-immune signaling
HPA axis
Online Access:http://www.mdpi.com/1420-3049/23/8/1836

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