A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

Hippocampal neurogenesis is important for certain forms of cognition, and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic capacity of hippocampal neural stem/progenitor cells (NSPCs) depends on a balance between quiescent and proliferative states. Here, we show...

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Bibliographic Details
Main Authors: Marlen Knobloch, Gregor-Alexander Pilz, Bart Ghesquière, Werner J. Kovacs, Thomas Wegleiter, Darcie L. Moore, Martina Hruzova, Nicola Zamboni, Peter Carmeliet, Sebastian Jessberger
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
neurogenesis
neural stem cell
hippocampus
beta-oxidation
metabolism
proliferation
quiescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311361

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