Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon

Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find ou...

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Main Authors: Astha Varma, Harish Padh, Neeta Shrivastava
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1093/ecam/nep135
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spelling doaj-ec0e987864fe4f6d863cdc9b7a3408632020-11-24T23:01:47ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1093/ecam/nep135815390Andrographolide: A New Plant-Derived Antineoplastic Entity on HorizonAstha Varma0Harish Padh1Neeta Shrivastava2B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej—Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, IndiaB. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej—Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, IndiaB. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej—Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, IndiaPlant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.http://dx.doi.org/10.1093/ecam/nep135
collection DOAJ
language English
format Article
sources DOAJ
author Astha Varma
Harish Padh
Neeta Shrivastava
spellingShingle Astha Varma
Harish Padh
Neeta Shrivastava
Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
Evidence-Based Complementary and Alternative Medicine
author_facet Astha Varma
Harish Padh
Neeta Shrivastava
author_sort Astha Varma
title Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
title_short Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
title_full Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
title_fullStr Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
title_full_unstemmed Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
title_sort andrographolide: a new plant-derived antineoplastic entity on horizon
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2011-01-01
description Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.
url http://dx.doi.org/10.1093/ecam/nep135
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