Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers

• Main Authors: Paul C Edwards, John E Fantasia
• Format: Article
• Language: English
• Published: Dove Medical Press 2008-01-01
• Series: Clinical Interventions in Aging
• Online Access: https://www.dovepress.com/review-of-long-term-adverse-effects-associated-with-the-use-of-chemica-peer-reviewed-article-CIA

Paul C Edwards1, John E Fantasia21Associate Professor (Clinical), Department of Periodontics and Oral Medicine, Pathology and Oncology, University of Michigan School of Dentistry, Ann Arbor MI, USA; 2Chief, Division of Oral Pathology, Department of Dental Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, USAAbstract: Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as “redefining” dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.Keywords: hyaluronic acid, Restylane®, Hylaform®, injectable dermal filler, foreign body reaction, granuloma