Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular endothelium (VE). The most principle mechanism might be excess reactive oxygen species (ROS) generation. Nevertheless, the characteristics of ROS generation, downstream mechanisms, and target organelles in Dox-induce...

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Bibliographic Details
Main Authors: Huan He, Liang Wang, Yang Qiao, Qing Zhou, Hongwei Li, Shuping Chen, Dong Yin, Qing Huang, Ming He
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
vascular endothelium
endotheliotoxicity
mitochondria
ROS/eNOS/NO pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01531/full

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