Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is...

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Bibliographic Details
Main Authors: Hrishikesh Pandit, Kavita Kale, Hidemi Yamamoto, Gargi Thakur, Sushama Rokade, Payal Chakraborty, Madavan Vasudevan, Uday Kishore, Taruna Madan, Raina Nakova Fichorova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
surfactant protein D
HIV-1
vaginal
microarray
chemokines
microbicide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00264/full

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