MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis....

Full description

Bibliographic Details
Main Authors: Jingyi Yu, Rong Lei, Xueqian Zhuang, Xiaoxun Li, Gang Li, Sima Lev, Miguel F. Segura, Xue Zhang, Guohong Hu
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13884
id doaj-ec0353b3c0b54b89a9b62aad167220c3
record_format Article
spelling doaj-ec0353b3c0b54b89a9b62aad167220c32021-05-11T10:57:01ZengNature Publishing GroupNature Communications2041-17232016-12-017111210.1038/ncomms13884MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cellsJingyi Yu0Rong Lei1Xueqian Zhuang2Xiaoxun Li3Gang Li4Sima Lev5Miguel F. Segura6Xue Zhang7Guohong Hu8The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesMolecular Cell Biology Department, Weizmann Institute of ScienceDepartment of Pathology, New York University School of MedicineThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of SciencesSMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.https://doi.org/10.1038/ncomms13884
collection DOAJ
language English
format Article
sources DOAJ
author Jingyi Yu
Rong Lei
Xueqian Zhuang
Xiaoxun Li
Gang Li
Sima Lev
Miguel F. Segura
Xue Zhang
Guohong Hu
spellingShingle Jingyi Yu
Rong Lei
Xueqian Zhuang
Xiaoxun Li
Gang Li
Sima Lev
Miguel F. Segura
Xue Zhang
Guohong Hu
MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
Nature Communications
author_facet Jingyi Yu
Rong Lei
Xueqian Zhuang
Xiaoxun Li
Gang Li
Sima Lev
Miguel F. Segura
Xue Zhang
Guohong Hu
author_sort Jingyi Yu
title MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_short MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_full MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_fullStr MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_full_unstemmed MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_sort microrna-182 targets smad7 to potentiate tgfβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-12-01
description SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.
url https://doi.org/10.1038/ncomms13884
work_keys_str_mv AT jingyiyu microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT ronglei microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT xueqianzhuang microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT xiaoxunli microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT gangli microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT simalev microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT miguelfsegura microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT xuezhang microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
AT guohonghu microrna182targetssmad7topotentiatetgfbinducedepithelialmesenchymaltransitionandmetastasisofcancercells
_version_ 1721447348823916544

Similar Items