METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD

METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD

A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18...

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Main Authors: A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomsky, G. L. Rusinov, V. L. Rusinov, G. A. Artem’ev, D. S. Kopchuk, V. N. Charushin
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:Разработка и регистрация лекарственных средств
Subjects:
5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininy
triazide
hplc
validation
Online Access:https://www.pharmjournal.ru/jour/article/view/581
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spelling doaj-ebf6dce434b24def95aa312d1ae2d3b32021-07-28T13:06:56ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01027883581METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHODA. V. Baklykov0A. A. Tumashov1S. K. Kotovskaya2E. N. Ulomsky3G. L. Rusinov4V. L. Rusinov5G. A. Artem’ev6D. S. Kopchuk7V. N. Charushin8I.Ya. Postovsky Institute of organic synthesis UB of RASI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RASI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinA procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation.https://www.pharmjournal.ru/jour/article/view/5815-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininytriazidehplcvalidation
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Baklykov
A. A. Tumashov
S. K. Kotovskaya
E. N. Ulomsky
G. L. Rusinov
V. L. Rusinov
G. A. Artem’ev
D. S. Kopchuk
V. N. Charushin
spellingShingle A. V. Baklykov
A. A. Tumashov
S. K. Kotovskaya
E. N. Ulomsky
G. L. Rusinov
V. L. Rusinov
G. A. Artem’ev
D. S. Kopchuk
V. N. Charushin
METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
Разработка и регистрация лекарственных средств
5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininy
triazide
hplc
validation
author_facet A. V. Baklykov
A. A. Tumashov
S. K. Kotovskaya
E. N. Ulomsky
G. L. Rusinov
V. L. Rusinov
G. A. Artem’ev
D. S. Kopchuk
V. N. Charushin
author_sort A. V. Baklykov
title METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
title_short METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
title_full METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
title_fullStr METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
title_full_unstemmed METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD
title_sort method of determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-<i>a</i>]pirimidinide <i>l-</i>argininy - the active component of drug «triazid» by hplc method
publisher LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
series Разработка и регистрация лекарственных средств
issn 2305-2066
2658-5049
publishDate 2019-01-01
description A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation.
topic 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l-argininy
triazide
hplc
validation
url https://www.pharmjournal.ru/jour/article/view/581
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