Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

While oxytocin is known to be critical for social recognition, the functions of oxytocin receptors (Oxtrs) in the hippocampus are not known. This study shows that Oxtrs in anterior dentate gyrus and CA2/CA3 pyramidal cells recruit population-based coding to mediate discrimination of social stimuli.

Bibliographic Details
Main Authors: Tara Raam, Kathleen M. McAvoy, Antoine Besnard, Alexa H. Veenema, Amar Sahay
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02173-0
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spelling doaj-ebf2b63d30ed4f07927a547ba3ada6f22021-05-11T07:13:39ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02173-0Hippocampal oxytocin receptors are necessary for discrimination of social stimuliTara Raam0Kathleen M. McAvoy1Antoine Besnard2Alexa H. Veenema3Amar Sahay4Center for Regenerative Medicine, Massachusetts General HospitalCenter for Regenerative Medicine, Massachusetts General HospitalCenter for Regenerative Medicine, Massachusetts General HospitalDepartment of Psychology, Michigan State UniversityCenter for Regenerative Medicine, Massachusetts General HospitalWhile oxytocin is known to be critical for social recognition, the functions of oxytocin receptors (Oxtrs) in the hippocampus are not known. This study shows that Oxtrs in anterior dentate gyrus and CA2/CA3 pyramidal cells recruit population-based coding to mediate discrimination of social stimuli.https://doi.org/10.1038/s41467-017-02173-0
collection DOAJ
language English
format Article
sources DOAJ
author Tara Raam
Kathleen M. McAvoy
Antoine Besnard
Alexa H. Veenema
Amar Sahay
spellingShingle Tara Raam
Kathleen M. McAvoy
Antoine Besnard
Alexa H. Veenema
Amar Sahay
Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
Nature Communications
author_facet Tara Raam
Kathleen M. McAvoy
Antoine Besnard
Alexa H. Veenema
Amar Sahay
author_sort Tara Raam
title Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
title_short Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
title_full Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
title_fullStr Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
title_full_unstemmed Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
title_sort hippocampal oxytocin receptors are necessary for discrimination of social stimuli
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description While oxytocin is known to be critical for social recognition, the functions of oxytocin receptors (Oxtrs) in the hippocampus are not known. This study shows that Oxtrs in anterior dentate gyrus and CA2/CA3 pyramidal cells recruit population-based coding to mediate discrimination of social stimuli.
url https://doi.org/10.1038/s41467-017-02173-0
work_keys_str_mv AT tararaam hippocampaloxytocinreceptorsarenecessaryfordiscriminationofsocialstimuli
AT kathleenmmcavoy hippocampaloxytocinreceptorsarenecessaryfordiscriminationofsocialstimuli
AT antoinebesnard hippocampaloxytocinreceptorsarenecessaryfordiscriminationofsocialstimuli
AT alexahveenema hippocampaloxytocinreceptorsarenecessaryfordiscriminationofsocialstimuli
AT amarsahay hippocampaloxytocinreceptorsarenecessaryfordiscriminationofsocialstimuli
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