Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity

The molecular action underlying peptide intervention before and after colitis induction is different. To investigate the alleviated effects of mulberry leaf protein hydrolysates (MLPH) on colitis and its potential mechanism, MLPH was administered to colitis mice. Results showed that MLPH efficiently...

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Main Authors: Chongzhen Sun, Xin Tang, Xin Shao, Duo Han, Hua Zhang, Yangwei Shan, Ravi Gooneratne, Lei Shi, Xiyang Wu, Marzieh Hosseininezhad
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Functional Foods
Subjects:
DSS
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621002243
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spelling doaj-ebf1eaf382a747dc956e6a348564842d2021-07-13T04:08:59ZengElsevierJournal of Functional Foods1756-46462021-09-0184104575Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunityChongzhen Sun0Xin Tang1Xin Shao2Duo Han3Hua Zhang4Yangwei Shan5Ravi Gooneratne6Lei Shi7Xiyang Wu8Marzieh Hosseininezhad9Department of Food Science and Engineering, Jinan University, Huangpu Road 601, Guangzhou 510632, Guangdong, ChinaDepartment of Food Science and Engineering, Jinan University, Huangpu Road 601, Guangzhou 510632, Guangdong, ChinaSchool of Medicine, South China University of Technology, Guangzhou 510640, Guangdong, ChinaDepartment of Food Science and Engineering, Jinan University, Huangpu Road 601, Guangzhou 510632, Guangdong, ChinaDepartment of Food Safety and Nutrition, School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi, ChinaDepartment of Food Science and Engineering, Jinan University, Huangpu Road 601, Guangzhou 510632, Guangdong, ChinaCentre for Food Research and Innovation, Lincoln University, Lincoln 7647, New ZealandInstitute of Food Safety and Nutrition, Jinan University, Huangpu Road 601, Guangzhou 510640, Guangdong, ChinaDepartment of Food Science and Engineering, Jinan University, Huangpu Road 601, Guangzhou 510632, Guangdong, China; Corresponding author.Department of Food Biotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, IranThe molecular action underlying peptide intervention before and after colitis induction is different. To investigate the alleviated effects of mulberry leaf protein hydrolysates (MLPH) on colitis and its potential mechanism, MLPH was administered to colitis mice. Results showed that MLPH efficiently alleviated the colitis, and the preventive and therapeutic (P&T) intervention was more effective than the therapeutic intervention alone. MLPH significantly decreased pro-inflammatory cytokines, improved histological damage, and increased SCFA contents. MLPH also reversed microbiota dysbiosis. The dominant genera in MLPH intervention group were significantly positively correlated with colitis prevention parameters (p < 0.01). The DSS group was the opposite. In addition, the dominant genera of MLPH intervention group showed a co-occurrence relationship with each other. Overall, MLPH could alleviate colitis by integrated modulation of gut microbiota and inflammation response. MLPH may be a promising dietary approach for sustaining gut health to lower the risk of developing colitis.http://www.sciencedirect.com/science/article/pii/S1756464621002243Mulberry leaf protein hydrolysatesColitisDSSGut microbiotaCorrelation analysisKey bacteria
collection DOAJ
language English
format Article
sources DOAJ
author Chongzhen Sun
Xin Tang
Xin Shao
Duo Han
Hua Zhang
Yangwei Shan
Ravi Gooneratne
Lei Shi
Xiyang Wu
Marzieh Hosseininezhad
spellingShingle Chongzhen Sun
Xin Tang
Xin Shao
Duo Han
Hua Zhang
Yangwei Shan
Ravi Gooneratne
Lei Shi
Xiyang Wu
Marzieh Hosseininezhad
Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
Journal of Functional Foods
Mulberry leaf protein hydrolysates
Colitis
DSS
Gut microbiota
Correlation analysis
Key bacteria
author_facet Chongzhen Sun
Xin Tang
Xin Shao
Duo Han
Hua Zhang
Yangwei Shan
Ravi Gooneratne
Lei Shi
Xiyang Wu
Marzieh Hosseininezhad
author_sort Chongzhen Sun
title Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
title_short Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
title_full Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
title_fullStr Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
title_full_unstemmed Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
title_sort mulberry (morus atropurpurea roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2021-09-01
description The molecular action underlying peptide intervention before and after colitis induction is different. To investigate the alleviated effects of mulberry leaf protein hydrolysates (MLPH) on colitis and its potential mechanism, MLPH was administered to colitis mice. Results showed that MLPH efficiently alleviated the colitis, and the preventive and therapeutic (P&T) intervention was more effective than the therapeutic intervention alone. MLPH significantly decreased pro-inflammatory cytokines, improved histological damage, and increased SCFA contents. MLPH also reversed microbiota dysbiosis. The dominant genera in MLPH intervention group were significantly positively correlated with colitis prevention parameters (p < 0.01). The DSS group was the opposite. In addition, the dominant genera of MLPH intervention group showed a co-occurrence relationship with each other. Overall, MLPH could alleviate colitis by integrated modulation of gut microbiota and inflammation response. MLPH may be a promising dietary approach for sustaining gut health to lower the risk of developing colitis.
topic Mulberry leaf protein hydrolysates
Colitis
DSS
Gut microbiota
Correlation analysis
Key bacteria
url http://www.sciencedirect.com/science/article/pii/S1756464621002243
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