Direct conversion of porcine primary fibroblasts into hepatocyte-like cells
Abstract The pig is an important model organism for biomedical research, mainly due to its extensive genetic, physiological and anatomical similarities with humans. Until date, direct conversion of somatic cells into hepatocyte-like cells (iHeps) has only been achieved in rodents and human cells. He...
Main Authors: | Mariane Fráguas-Eggenschwiler, Reto Eggenschwiler, Jenny-Helena Söllner, Leon Cortnumme, Florian W. R. Vondran, Tobias Cantz, Michael Ott, Heiner Niemann |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-88727-1 |
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